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Papers of the Week

Papers: 29 May 2021 - 4 Jun 2021

Human Studies


J Pain Res


Effects of Polymorphisms in the Serotonin Transporter Promoter-Linked Polymorphic Region on Postthoracotomy Pain Severity.


Kimura A, Yamasaki H, Ishii H, Yoshida H, Shimizu M, Mori T
J Pain Res. 2021; 14:1389-1397.
PMID: 34079356.


Serotonin (5-HT) is highly associated with pain modulation. The human 5-HT transporter (5-HTT) gene (SLC6A4) features several polymorphisms in its promoter region (5-HTTLPR) that affect the 5-HTT expression. The S allele of 5-HTTLPR induces low 5-HT tone, and it may influence the modulation of chronic pain. Meanwhile, pain occurs in 40-50% of patients after thoracic surgery, and its mechanism remains under investigation. This study assessed the role of 5-HTTLPR polymorphisms in postthoracotomy pain severity.