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Papers of the Week

Papers: 29 May 2021 - 4 Jun 2021

Human Studies



Front Physiol


Cerebrovascular Reactivity Measures Are Associated With Post-traumatic Headache Severity in Chronic TBI; A Retrospective Analysis.


Amyot F, Lynch CE, Ollinger J, Werner KJ, Silverman E, Moore C, Davis C, Turtzo CL, Diaz-Arrastia R, Kenney K
Front Physiol. 2021; 12:649901.
PMID: 34054569.


To characterize the relationship between persistent post-traumatic headache (pPTH) and traumatic cerebrovascular injury (TCVI) in chronic traumatic brain injury (TBI). Cerebrovascular reactivity (CVR), a measure of the cerebral microvasculature and endothelial cell function, is altered both in individuals with chronic TBI and migraine headache disorder (Amyot et al., 2017; Lee et al., 2019b). The pathophysiologies of pPTH and migraine are believed to be associated with chronic microvascular dysfunction. We therefore hypothesize that TCVI may contribute to the underlying migraine-like mechanism(s) of pPTH.