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Papers of the Week


2021


Methods Mol Biol


2321

Analgesia and Humane Endpoints for Rodents in Sepsis Research.

Authors

Boehm CA, Nemzek JA
Methods Mol Biol. 2021; 2321:221-229.
PMID: 34048020.

Abstract

Numerous regulatory bodies around the world require analgesics for rodents undergoing surgery to induce sepsis. Well-controlled pain will decrease morbidity. Options for analgesics include NSAIDs, local analgesics, and opioids. Supportive care can also decrease stress to post-operative animals. As well, humane endpoints should be agreed upon before the study commences so as to alleviate unnecessary pain and distress.