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Papers of the Week

Papers: 22 May 2021 - 28 May 2021

Human Studies


J Pain Res


Central Sensitization in Chronic Low Back Pain: A Population-Based Study of a Japanese Mountain Village.


Akeda K, Takegami N, Yamada J, Fujiwara T, Nishimura A, Sudo A
J Pain Res. 2021; 14:1271-1280.
PMID: 34040431.


Central sensitization (CS) is defined as the increased responsiveness of nociceptive neurons in the central nervous system to normal or subthreshold afferent input. CS has been proposed as an underlying mechanism of chronic pain in musculoskeletal disorders including low back pain (LBP). A Central Sensitization Inventory (CSI) has recently been developed for screening participants with CS. However, the association of CS with chronic LBP (cLBP) in the general population remains unknown. The purpose of this study was to investigate the association of CS with cLBP using the CSI in a population-based cohort of a Japanese mountain village.