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Papers of the Week

Papers: 22 May 2021 - 28 May 2021


2021 May 19

J Invest Dermatol

Periostin, an Emerging Player in Itch Sensation.


Hashimoto T, Mishra SK, Olivry T, Yosipovitch G
J Invest Dermatol. 2021 May 19.
PMID: 34023128.


Periostin, an extracellular matrix and matricellular protein, binds to several types of integrins that transduce its signals. Its function in allergic inflammation is the establishment of sustained chronic inflammation through an amplification of T helper type 2‒immune responses. In addition, recent studies have shown a significant role of periostin in itch sensation through direct integrin-mediated stimulation of nerve fibers and interaction with immune and nonimmune cells (e.g., macrophages, eosinophils, basophils, and keratinocytes). The objective of this review is to describe the role of periostin in itch induction in human and animal models and its expression in human pruritic conditions.