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Papers of the Week

Papers: 22 May 2021 - 28 May 2021

Human Studies

2021 May 23

Eur Spine J

Low back pain scores correlate with the cytokine mRNA level in lumbar disc biopsies: a study of inflammatory markers in patients undergoing lumbar spinal fusion.


Aripaka SS, Bech-Azeddine R, Jørgensen LM, Chughtai SA, Gaarde C, Bendix T, Mikkelsen JD
Eur Spine J. 2021 May 23.
PMID: 34023967.


The molecular mechanism behind pain in degenerative disc disease (DDD) and chronic low back pain (LBP) patients is largely unknown. This present study examines the association of LBP and disability to mediators of the inflammatory cascade, as indexed by mRNA gene expression of pro-inflammatory cytokine markers in the intervertebral disc (IVD).