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Papers of the Week

2021 May 18

Curr Drug Deliv

Novel Self-Micro Emulsifying Drug Delivery System for safe intra muscular delivery with improved pharmacodynamics and pharmacokinetics.


Jain S K, Panchal N, Singh A, Thakur S, Shahtaghi N R, Sharma S, Guleria A
Curr Drug Deliv. 2021 May 18.
PMID: 34011257.


Diclofenac sodium (DS) injection is widely used in the management of acute or chronic pain and inflammatory diseases. It incorporates 20 % w/v Transcutol-P as a solubilizer to make the stable injectable formulation. However, the use of Transcutol-P in high concentration leads to adverse effects such as severe nephrotoxicity, etc. Some advancements resulted in the formulation of an aqueous based injectable but that too used benzyl alcohol reported to be toxic for human use.