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Papers of the Week

2021 May 20


Efficacy and safety of opioid therapy guided by pharmacogenetics (PGx): a systematic review.


Rodriguez Cairoli F, Appiani F, Sambade J M, Comandé D, Camacho Arteaga L, Ciapponi A
Pharmacogenomics. 2021 May 20.
PMID: 34013775.


To perform a systematic review to determine the efficacy/safety of PGx-guided opioid therapy for chronic/postoperative pain. We searched PubMed and other specialized databases. Articles were considered if they compared the efficacy/safety of PGx-guided opioid therapy versus usual care. The risk of bias assessment was performed using Cochrane tools. A total of 3794 records were retrieved. Only five were included for data extraction. A lower requirement of analgesics during postoperative in the PGx-guided intervention arm was reported in two studies. Also, two studies reported significant pain improvement in favor of the PGx-guided therapy when analyzing the subgroup of patients with a high-risk CYP2D6 phenotype. Despite the findings described, information on the efficacy/safety of this intervention is scarce.