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Papers of the Week

2021 May 21

Acta Neurol Scand

Refractory migraine profile in CGRP-monoclonal antibodies scenario.


Silvestro M, Tessitore A, Scotto di Clemente F, Battista G, Tedeschi G, Russo A
Acta Neurol Scand. 2021 May 21.
PMID: 34019304.


Refractory migraine (Ref-M) represents a conundrum that headache experts have to face with. We aim to investigate whether a peculiar profile may characterize patients with Ref-M according to 2020 European Headache Federation criteria. Furthermore, to substantiate a dysfunctional dopaminergic pathway involvement in these patients, we explored the effectiveness of olanzapine.