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Papers of the Week

2021 May 21

J Neurosurg Spine

Abnormal spinal cord motion at the craniocervical junction in hypermobile Ehlers-Danlos patients.


Klinge PM, McElroy A, Donahue JE, Brinker T, Gokaslan ZL, Beland MD
J Neurosurg Spine. 2021 May 21:1-7.
PMID: 34020423.


The craniocervical junction (CCJ) is anatomically complex and comprises multiple joints that allow for wide head and neck movements. The thecal sac must adjust to such movements. Accordingly, the thecal sac is not rigidly attached to the bony spinal canal but instead tethered by fibrous suspension ligaments, including myodural bridges (MDBs). The authors hypothesized that pathological spinal cord motion is due to the laxity of such suspension bands in patients with connective tissue disorders, e.g., hypermobile Ehlers-Danlos syndrome (EDS).