I am a
Home I AM A Search Login

Papers of the Week

Papers: 15 May 2021 - 21 May 2021

2021 Mar 26

Curr Opin Support Palliat Care

Pain in Parkinson’s disease: Mechanism-based treatment strategies.


Rukavina K, Cummins TM, Chaudhuri RK, Bannister K
Curr Opin Support Palliat Care. 2021 Mar 26.
PMID: 34009822.


Chronic pain, highly prevalent throughout the course of Parkinson's disease (PD), has been ranked as one of the top ten most bothersome symptoms people with Parkinson's (PwP) are experiencing. Yet, robust evidence-based treatment strategies are lacking. This unmet need is partly attributable to the multifaceted nature of PD-related pain, which results in part from a complex and poorly understood interplay involving a range of neurotransmitter pathways. Degeneration of nigrostriatal dopaminergic pathways and alterations of central nervous system extra-striatal dopaminergic, noradrenergic, serotoninergic, glutamatergic, opioidergic and endocannabinoid circuits may all promote a heightened experience of pain in PwP. Thus, the potential targets for mechanism-based pain-relieving strategies in PwP are several. These targets are discussed herein.