I am a
Home I AM A Search Login

Papers of the Week

2020 Dec 30

Can J Pain



A mini-review: Bridging the gap between autism spectrum disorder and pain comorbidities.


Brown CO, Uy J, Singh KK
Can J Pain. 2020 Dec 30; 4(4):37-44.
PMID: 33987518.


Pain is a complex neurobiological response with a multitude of causes; however, patients with autism spectrum disorder (ASD) often report chronic pain with no known etiology. Recent research has been aimed toward identifying the causal mechanisms of pain in mouse and human models of ASD. In recent years, efforts have been made to better document and explore secondary phenotypes observed in ASD patients in the clinic. As new sequencing studies have become more powered with larger cohorts within ASD, specific genes and their variants are often left uncharacterized or validated. In this review we highlight ASD risk genes often presented with pain comorbidities.