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Papers of the Week

Papers: 15 May 2021 - 21 May 2021

Animal Studies, Pharmacology/Drug Development

2021 May 14

Br J Pharmacol

Inhibition of inflammatory pain and cough by a novel charged sodium channel blocker.


Tochitsky I, Jo S, Andrews N, Kotoda M, Doyle B, Shim J, Talbot S, Roberson D, Lee J, Haste L, Jordan SM, Levy BD, Bean BP, Woolf CJ
Br J Pharmacol. 2021 May 14.
PMID: 33988876.


Many pain-triggering nociceptor neurons express TRPV1 or TRPA1, cation-selective channels with large pores that enable permeation of QX-314, a cationic analogue of lidocaine. Co-application of QX-314 with TRPV1 or TRPA1 activators can silence nociceptors. In this study, we describe BW-031, a novel more potent cationic sodium channel inhibitor, test whether its application alone can inhibit pain associated with tissue inflammation, and whether this strategy can also inhibit cough.