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Papers of the Week

2021 May 11

J Mol Cell Cardiol

Increasing fatty acid oxidation elicits a sex-dependent response in failing mouse hearts.


Ritterhoff J, McMillen TS, Villet O, Young S, Kolwicz SC, Senn T, Caudal A, Tian R
J Mol Cell Cardiol. 2021 May 11.
PMID: 33989657.


Reduced fatty acid oxidation (FAO) is a hallmark of metabolic remodeling in heart failure. Enhancing mitochondrial long-chain fatty acid uptake by Acetyl-CoA carboxylase 2 (ACC2) deletion increases FAO and prevents cardiac dysfunction during chronic stresses, but therapeutic efficacy of this approach has not been determined.