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Papers of the Week

Papers: 8 May 2021 - 14 May 2021

Animal Studies, Pharmacology/Drug Development

2021 May 12

Eur J Pain

Amantadine Prevented Hypersensitivity and Decreased Oxidative Stress by NMDA Receptor Antagonism after Spinal Cord Injury in Rats.


Mata-Bermudez A, Ríos C, Burelo M, Pérez-González C, García-Martínez BA, Jardon-Guadarrama G, Calderón-Estrella F, Manning-Balpuesta N, Diaz-Ruiz A
Eur J Pain. 2021 May 12.
PMID: 33982314.


Neuropathic pain (NP) after spinal cord injury (SCI) is a disabling condition, without an effective treatment. Hyperexcitability of N-methyl-D-aspartate (NMDA) receptors and oxidative stress have been reported to be associated with pain development. Amantadine, a NMDA receptor antagonist, has been proposed as a potential therapy for NP. However, its use has not been tested for NP after SCI.