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Papers of the Week

Papers: 8 May 2021 - 14 May 2021

Animal Studies, Pharmacology/Drug Development


J Pain Res


Ulinastatin Exhibits Antinociception in Rat Models of Acute Somatic and Visceral Pain Through Inhibiting the Local and Central Inflammation.


Zhan M-X, Tang L, Lu Y-F, Wu H-H, Guo Z-B, Shi Z-M, Yang C-L, Zou Y-Q, Yang F, Chen G-Z
J Pain Res. 2021; 14:1201-1214.
PMID: 33976570.


Ulinastatin, a broad-spectrum serine protease inhibitor, has been widely used to treat various diseases clinically. However, so far, the antinociceptive effect of ulinastatin remains less studied experimentally and the underlying mechanisms of ulinastatin for pain relief remain unclear. This study aimed to find evidence of the analgesic effect of ulinastatin on acute somatic and visceral pain.