I am a
Home I AM A Search Login

Papers of the Week

Papers: 8 May 2021 - 14 May 2021

Animal Studies

2021 May 12

J Neural Eng

Mapping the peripheral nervous system in the whole mouse via compressed sensing tractography.


O'Raw A D, Rakhilin N, Wang N, McKey J, Cofer G, Anderson R B, Capel B, Johnson AG, Shen X
J Neural Eng. 2021 May 12.
PMID: 33979784.


The peripheral nervous system (PNS) connects the central nervous system (CNS) with the rest of the body to regulate many physiological functions and is therapeutically targeted to treat diseases such as epilepsy, depression, intestinal dysmotility, chronic pain, and more. However, we still lack understanding of PNS innervation in most organs because the large span, diffuse nature, and small terminal nerve bundle fibers have precluded whole-organism, high resolution mapping of the PNS. We sought to produce a comprehensive peripheral nerve atlas for use in future interrogation of neural circuitry and selection of targets for neuromodulation.