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Papers of the Week

2021 May 08

BMC Gastroenterol



Anti-IL-4Ralpha monoclonal antibody dupilumab mimics ulcerative colitis: a case report.


Shimodaira Y, Takahashi S, Iijima K
BMC Gastroenterol. 2021 May 08; 21(1):207.
PMID: 33964871.


Various molecular-targeted therapeutic agents that inhibit cytokines and immune checkpoints are used in clinical practice. Some of these biologics that control immunity, such as anti-interleukin-17, anti-programmed cell death protein-1, and anti-cytotoxic T-lymphocyte-associated protein antibodies, affect intestinal immune homeostasis and cause intestinal inflammation. Development of enteritis due to dupilumab (an anti-IL-4Ralpha monoclonal antibody) therapy is not yet reported in the literature.