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Papers of the Week

2021 May 06

World J Clin Cases



Treatment of acute severe ulcerative colitis using accelerated infliximab regimen based on infliximab trough level: A case report.


de Garate A L S V, Rocha T B, Almeida L R, Quera R, Barros J R, Baima J P, Saad-Hossne R, Sassaki L Y
World J Clin Cases. 2021 May 06; 9(13):3219-3226.
PMID: 33969111.


Acute severe ulcerative colitis (ASUC) is a complication of ulcerative colitis associated with high levels of circulating tumor necrosis factor alpha, due to the intense inflammation and faster stool clearance of anti-tumor necrosis factor drugs. Dose-intensified infliximab treatment can be beneficial and is associated with lower rates of colectomy. The aim of the study was to present a case of a patient with ASUC and megacolon, treated with hydrocortisone and accelerated scheme of infliximab that was monitored by drug trough level.