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Papers of the Week

2021 May 07

Int J Retina Vitreous



Mechanisms of sterile inflammation after intravitreal injection of antiangiogenic drugs: a narrative review.


Anderson WJ, da Cruz N F S, Lima L H, Emerson GG, Rodrigues E B, Melo G B
Int J Retina Vitreous. 2021 May 07; 7(1):37.
PMID: 33962696.


Intraocular inflammation is an uncommon but potentially vision-threatening adverse event related to anti-VEGF therapy. This is of increasing importance given both the volume of injections performed, as well as the increased prevalence of inflammation seen with newer anti-VEGF agents. Brolucizumab, the newest anti-VEGF agent, has been associated with an inflammatory retinal vasculitis and the underlying mechanism is unclear. Reviewing potential mechanisms and clinical differences of intraocular inflammation may assist clinicians and scientists in reducing the risk of these events in the future.