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Papers of the Week

Papers: 8 May 2021 - 14 May 2021

Human Studies, Pharmacology/Drug Development




Do gabapentin or pregabalin directly modulate the µ receptor?


Manandhar P, Murnion B P, Grimsey NL, Connor M, Santiago M
PeerJ. 2021; 9:e11175.
PMID: 33954038.


Pregabalin and gabapentin improve neuropathic pain symptoms but there are emerging concerns regarding their misuse. This is more pronounced among patients with substance use disorder, particularly involving opioids. Co-ingestion of gabapentinoids with opioids is increasingly identified in opioid related deaths, however, the molecular mechanism behind this is still unclear. We have sought to determine whether pregabalin or gabapentin directly modulates acute μ receptor signaling, or μ receptor activation by morphine.