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Papers of the Week

2021 May 04

Life Sci

Antinociceptive synergism upon the joint use of methadone and Phα1β in a model of cancer-related pain in C57BL/6J mice.


Ferreira LA, Aoki CT, Dos Santos DC, Rezende MJ, Mendes M P, Moura RA, Delgado MA, Ferreira J, Gomez MV, Castro Junior CJ
Life Sci. 2021 May 04:119582.
PMID: 33961856.


Opioids are the first-line treatment for cancer pain. Incomplete pain relief and the high rate of adverse effects of these compounds bring a need to combine them with other drugs acting on different targets.