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Papers of the Week

2021 May 07

J Neurosurg

Silent corticotroph pituitary adenomas: clinical characteristics, long-term outcomes, and management of disease recurrence.


Strickland BA, Shahrestani S, Briggs RG, Jackanich A, Tavakol S, Hurth K, Shiroishi MS, Liu C-SJ, Carmichael JD, Weiss M, Zada G
J Neurosurg. 2021 May 07:1-8.
PMID: 33962375.


Silent corticotroph adenomas (SCAs) are a distinct subtype of nonfunctioning pituitary adenomas (NFAs) that demonstrate positive immunohistochemistry for adrenocorticotropic hormone (ACTH) without causing Cushing's disease. SCAs are hypothesized to exhibit more aggressive behavior than standard NFAs. The authors analyzed their institution's surgical experience with SCAs in an effort to characterize rates of invasion, postoperative clinical outcomes, and patterns of disease recurrence and progression. The secondary objectives were to define the best treatment strategies in the event of tumor recurrence and progression.