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Papers of the Week

2021 Apr 30

Anesth Analg

Volutrauma Increases Exhaled Pentanal in Rats: A Potential Breath Biomarker for Ventilator-Induced Lung Injury.


Müller-Wirtz L M, Kiefer D, Maurer F, Floss M A, Doneit J, Hüppe T, Shopova T, Wolf B, Sessler DI, Volk T, Kreuer S, Fink T
Anesth Analg. 2021 Apr 30.
PMID: 33929393.


Mechanical ventilation injures lungs, but there are currently no reliable methods for detecting early injury. We therefore evaluated whether exhaled pentanal, a lipid peroxidation product, might be a useful breath biomarker for stretch-induced lung injury in rats.