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PLoS One



Achalasia is associated with a higher incidence of depression in outpatients in Germany.


Loosen SH, Kandler J, Luedde T, Kostev K, Roderburg C
PLoS One. 2021; 16(4):e0250503.
PMID: 33930060.


Achalasia represents a chronic motility disorder of the esophagus featuring an impaired lower esophageal sphincter relaxation and loss of esophageal peristalsis. By causing dysphagia, regurgitation, aspiration and chest pain, achalasia might tremendously affect life quality of patients. However, the impact of achalasia on the development of mood disorders including depression has largely remained unclear. The aim of this study was to evaluate the incidence of depression in achalasia patients.