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Papers of the Week

2021 Apr 15

Cochrane Database Syst Rev


Transcranial magnetic stimulation for the treatment of epilepsy.


Walton D, Spencer DC, Nevitt SJ, Michael BD
Cochrane Database Syst Rev. 2021 Apr 15; 4:CD011025.
PMID: 33884611.


Epilepsy is a highly prevalent neurological condition characterised by repeated unprovoked seizures with various aetiologies. Although antiepileptic medications produce clinical improvement in many individuals, nearly a third of individuals have drug-resistant epilepsy that carries significant morbidity and mortality, and even individuals who have clinical improvement from antiepileptic medications often report iatrogenic symptoms. There remains a need for non-invasive and more effective therapies for this population. Transcranial magnetic stimulation (TMS) uses electromagnetic coils to excite or inhibit neurons, with repetitive pulses at low-frequency producing an inhibitory effect that could conceivably reduce cortical excitability associated with epilepsy. This is an updated version of the original Cochrane Review published in 2016.