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Papers of the Week

2021 Apr 22

J Psychopharmacol

Rodent models for nicotine withdrawal.


Chellian R, Behnood-Rod A, Bruijnzeel DM, Wilson R, Pandy V, Bruijnzeel AW
J Psychopharmacol. 2021 Apr 22:2698811211005629.
PMID: 33888006.


Animal models are critical to improve our understanding of the neuronal mechanisms underlying nicotine withdrawal. Nicotine dependence in rodents can be established by repeated nicotine injections, chronic nicotine infusion via osmotic minipumps, oral nicotine intake, tobacco smoke exposure, nicotine vapor exposure, and e-cigarette aerosol exposure. The time course of nicotine withdrawal symptoms associated with these methods has not been reviewed in the literature.