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Papers of the Week

Papers: 10 Apr 2021 - 16 Apr 2021

Animal Studies

2021 Apr 07

Arthritis Res Ther



The role of intra-articular neuronal CCR2 receptors in knee joint pain associated with experimental osteoarthritis in mice.


Ishihara S, Obeidat AM, Wokosin DL, Ren D, Miller RJ, Malfait A-M, Miller RE
Arthritis Res Ther. 2021 Apr 07; 23(1):103.
PMID: 33827672.


C-C chemokine receptor 2 (CCR2) signaling plays a key role in pain associated with experimental murine osteoarthritis (OA) after destabilization of the medial meniscus (DMM). Here, we aimed to assess if CCR2 expressed by intra-articular sensory neurons contributes to knee hyperalgesia in the early stages of the model.