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Papers of the Week

Home / Publications / Pain Research Forum / Papers of the Week / Dexmedetomidine Attenuates Ischemia/Reperfusion-Induced Myocardial Inflammation and Apoptosis Through Inhibiting Endoplasmic Reticulum Stress Signaling.

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2021


J Inflamm Res


http://www.ncbi.nlm.nih.gov/pubmed/33833544?dopt=Abstract


14

Dexmedetomidine Attenuates Ischemia/Reperfusion-Induced Myocardial Inflammation and Apoptosis Through Inhibiting Endoplasmic Reticulum Stress Signaling.

Authors

Dexmedetomidine Attenuates Ischemia/Reperfusion-Induced Myocardial Inflammation and Apoptosis Through Inhibiting Endoplasmic Reticulum Stress Signaling.
Yang Y-F, Wang H, Song N, Jiang Y-H, Zhang J, Meng X-W, Feng X-M, Liu H, Peng K, Ji F-H
J Inflamm Res. 2021; 14:1217-1233.
PMID: 33833544.

Abstract

Endoplasmic reticulum stress (ERS)-mediated myocardial inflammation and apoptosis plays an important role in myocardial ischemia/reperfusion (I/R) injury. Dexmedetomidine has been used clinically with sedative, analgesic, and anti-inflammatory properties. This study aimed to determine the effects of dexmedetomidine pretreatment on inflammation, apoptosis, and the expression of ERS signaling during myocardial I/R injury.
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