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Papers of the Week

Papers: 10 Apr 2021 - 16 Apr 2021

Animal Studies, Pharmacology/Drug Development


J Pain Res


Antinociceptive Effect of Lodenafil Carbonate in Rodent Models of Inflammatory Pain and Spinal Nerve Ligation-Induced Neuropathic Pain.


Vieira M C, de Monte F B M, Eduardo Dematte B, Montagnoli T L, Montes G C, da Silva J S, Mendez-Otero R, Trachez M M, Sudo R T, Zapata-Sudo G
J Pain Res. 2021; 14:857-866.
PMID: 33833563.


New therapeutic alternatives for pain relief include the use of phosphodiesterase-5 (PDE5) inhibitors, which could prevent the transmission of painful stimuli by neuron hyperpolarization via nitric oxide (NO)/cyclic 3',5'-guanosine monophosphate (cGMP) pathway. The present work investigated the antinociceptive activity of a new PDE5 inhibitor, lodenafil carbonate, in inflammatory and neuropathic pain models.