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Papers of the Week


Papers: 3 Apr 2021 - 9 Apr 2021


Animal Studies, Pharmacology/Drug Development

PAIN TYPE:
Itch


2021 Apr 02


J Allergy Clin Immunol

Targeted inhibition of EPAS1-driven IL-31 production by a small-molecule compound.

Authors

Kamikaseda Y, Uruno T, Kunimura K, Harada A, Saiki K, Oisaki K, Sakata D, Nakahara T, Kido-Nakahara M, Kanai M, Nakamura S, Ohkawa Y, Furue M, Fukui Y
J Allergy Clin Immunol. 2021 Apr 02.
PMID: 33819507.

Abstract

IL-31 is a major pruritogen associated with atopic dermatitis (AD). Although a specific antibody for IL-31 receptor has been shown to alleviate pruritus in patients with AD, therapeutic approaches to inhibit IL-31 production remain unexploited. IL-31 production by helper T cells critically depends on the transcription factor EPAS1, which mediates IL31 promoter activation in collaboration with SP1.