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Papers of the Week

Papers: 3 Apr 2021 - 9 Apr 2021


2021 Apr 01


A link between gastrointestinal disorders and migraine: Insights into the gut-brain connection.


Aurora SK, Shrewsbury SB, Ray S, Hindiyeh N, Nguyen L
Headache. 2021 Apr 01.
PMID: 33793965.


Migraine is a complex, multifaceted, and disabling headache disease that is often complicated by gastrointestinal (GI) conditions, such as gastroparesis, functional dyspepsia, and cyclic vomiting syndrome (CVS). Functional dyspepsia and CVS are part of a spectrum of disorders newly classified as disorders of gut-brain interaction (DGBI). Gastroparesis and functional dyspepsia are both associated with delayed gastric emptying, while nausea and vomiting are prominent in CVS, which are also symptoms that commonly occur with migraine attacks. Furthermore, these gastric disorders are comorbidities frequently reported by patients with migraine. While very few studies assessing GI disorders in patients with migraine have been performed, they do demonstrate a physiological link between these conditions.