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Papers of the Week

Papers: 27 Mar 2021 - 2 Apr 2021


2021 Mar 25


Migraine: disease characterisation, biomarkers, and precision medicine.


Ashina M, Terwindt GM, Al-Karagholi M A-M, de Boer I, Lee M J, Hay DL, Schulte LH, Hadjikhani N, Sinclair AJ, Ashina H, Schwedt TJ, Goadsby PJ
Lancet. 2021 Mar 25.
PMID: 33773610.


Migraine is a disabling neurological disorder, diagnosis of which is based on clinical criteria. A shortcoming of these criteria is that they do not fully capture the heterogeneity of migraine, including the underlying genetic and neurobiological factors. This complexity has generated momentum for biomarker research to improve disease characterisation and identify novel drug targets. In this Series paper, we present the progress that has been made in the search for biomarkers of migraine within genetics, provocation modelling, biochemistry, and neuroimaging research. Additionally, we outline challenges and future directions for each biomarker modality. We also discuss the advances made in combining and integrating data from multiple biomarker modalities. These efforts contribute to developing precision medicine that can be applied to future patients with migraine.