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Papers of the Week

Papers: 27 Mar 2021 - 2 Apr 2021

Animal Studies

2021 Mar 24

Life Sci


Plantar incision with severe muscle injury can be a cause of long-lasting postsurgical pain in the skin.


Yoshiyama Y, Sugiyama Y, Ishida K, Fuseya S, Tanaka S, Kawamata M
Life Sci. 2021 Mar 24; 275:119389.
PMID: 33774031.


Although chronic local inflammation in deeper tissues after skin wound healing might produce chronification of acute postsurgical pain, its mechanisms have not been fully elucidated. We hypothesized that muscle injury and severe inflammation would prolong acute postsurgical pain by its central nervous system mechanisms.