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Papers of the Week

2021 Mar 24

Curr Alzheimer Res

Piper sarmentosum Roxb. Attenuates Beta Amyloid (Aβ)-Induced Neurotoxicity Via the Inhibition of Amyloidogenesis and Tau Hyperphosphorylation in SH-SY5Y Cells.


Chan E W L, Yeo E T Y, Wong K W L, See M L, Wong K Y, Yap J K Y, Gan S Y
Curr Alzheimer Res. 2021 Mar 24.
PMID: 33761853.


In Alzheimer's disease, accumulation of beta amyloid (Aβ) triggers amyloidogenesis and hyperphosphorylation of tau protein leading to neuronal cell death. Piper sarmentosum Roxb. (PS) is a traditional medicinal herb used by Malay to treat rheumatism, headache and boost memory. It possesses various biological effects, such as anti-cholinergic, anti-inflammatory, anti-oxidant and anti-depressant-like effects.