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Papers of the Week

2021 Mar 25

Aliment Pharmacol Ther

Combination of fibrates with obeticholic acid is able to normalise biochemical liver tests in patients with difficult-to-treat primary biliary cholangitis.


Soret P-A, Lam L, Carrat F, Smets L, Berg T, Carbone M, Invernizzi P, Leroy V, Trivedi P, Cazzagon N, Weiler-Normann C, Alric L, Rosa-Hezode I, Heurgué A, Cervoni J-P, Dumortier J, Potier P, Roux O, Silvain C, Bureau C, et al.
Aliment Pharmacol Ther. 2021 Mar 25.
PMID: 33764590.


Obeticholic acid (OCA) and fibrates are second-line therapies for patients with primary biliary cholangitis (PBC) with an inadequate response to ursodeoxycholic acid (UDCA).