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Papers of the Week

Papers: 27 Mar 2021 - 2 Apr 2021

Human Studies


2021 Mar 26


Opening of ATP sensitive potassium channels causes migraine attacks with aura.


Al-Karagholi M A-M, Ghanizada H, Nielsen C A W, Hougaard A, Ashina M
Brain. 2021 Mar 26.
PMID: 33768245.


Migraine afflicts more than one billion individuals worldwide and is a leading cause of years lived with disability. In about a third of individuals with migraine aura occur in relation to migraine headache. The common pathophysiological mechanisms underlying migraine headache and migraine aura are yet to be identified. Based on recent data, we hypothesized that levcromakalim, an ATP-sensitive potassium channel opener, would trigger migraine attacks with aura in migraine with aura patients.