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Papers of the Week

Papers: 20 Mar 2021 - 26 Mar 2021

Animal Studies, Pharmacology/Drug Development

2021 Mar 25

Psychopharmacology (Berl)

Lack of effect of different pain-related manipulations on opioid self-administration, reinstatement of opioid seeking, and opioid choice in rats.


Reiner DJ, Townsend AE, Orihuel J, Applebey SV, Claypool SM, Banks ML, Shaham Y, Negus SS
Psychopharmacology (Berl). 2021 Mar 25.
PMID: 33765177.


Pain-related factors increase the risk for opioid addiction, and pain may function as a negative reinforcer to increase opioid taking and seeking. However, experimental pain-related manipulations generally do not increase opioid self-administration in rodents. This discrepancy may reflect insufficient learning of pain-relief contingencies or confounding effects of pain-related behavioral impairments. Here, we determined if pairing noxious stimuli with opioid self-administration would promote pain-related reinstatement of opioid seeking or increase opioid choice over food.