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Papers: 20 Mar 2021 - 26 Mar 2021

2021 Mar 23

Eur J Pain

Human surrogate models of central sensitization: a critical review and practical guide.


Quesada C, Kostenko A, Ho I, Leone C, Nochi Z, Stouffs A, Wittayer M, Caspani O, Finnerup N B, Mouraux A, Pickering G, Tracey I, Truini A, Treede R-D, Garcia-Larrea L
Eur J Pain. 2021 Mar 23.
PMID: 33759294.


As in other fields of medicine, development of new medications for management of neuropathic pain has been difficult since preclinical rodent models do not necessarily translate to the clinics. Aside from ongoing pain with burning or shock-like qualities, neuropathic pain is often characterized by pain hypersensitivity (hyperalgesia and allodynia), most often towards mechanical stimuli, reflecting sensitization of neural transmission.