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Papers of the Week

Papers: 20 Mar 2021 - 26 Mar 2021

2021 Mar 24

Curr Pain Headache Rep



Dual Enkephalinase Inhibitors and Their Role in Chronic Pain Management.


Southerland WA, Gillis J, Kuppalli S, Fonseca A, Mendelson A, Horine SV, Bansal N, Gulati A
Curr Pain Headache Rep. 2021 Mar 24; 25(5):29.
PMID: 33761014.


Dual enkephalinase inhibitors (DENKIs) are pain medications that indirectly activate opioid receptors and can be used as an alternative to traditional opioids. Understanding the physiology of enkephalins and their inhibitors and the pharmacology of these drugs will allow for proper clinical application for chronic pain patients in the future.