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Papers of the Week

2021 Mar 17

BMC Anesthesiol



TNF-α – mediated peripheral and central inflammation are associated with increased incidence of PND in acute postoperative pain.



Acute postoperative pain plays an important role in the perioperative neurocognitive disorders (PND). The pathogenesis of PND is still unknown, but it is generally believed that peripheral and central nervous system inflammation play an important role, and acute postoperative pain is also thought to aggravate postoperative inflammatory response. The aim of the present study is to explore the effect of acute postoperative pain on peripheral and central nervous system inflammation and related cognitive impairment behaviour in elderly rats after surgery.