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Papers of the Week

2021 Mar 12

BMC Musculoskelet Disord



Pentosan polysulfate sodium for Ross River virus-induced arthralgia: a phase 2a, randomized, double-blind, placebo-controlled study.


Krishnan R, Duiker M, Rudd PA, Skerrett D, Pollard JGD, Siddel C, Rifat R, Ng JHK, Georgius P, Hererro LJ, Griffin P
BMC Musculoskelet Disord. 2021 Mar 12; 22(1):271.
PMID: 33711991.


Alphaviruses, such as Ross River (RRV) and chikungunya virus (CHIKV), cause significant global morbidity, with outbreaks of crippling joint inflammation and pain, leaving patients incapacitated for months to years. With no available vaccine or specific therapeutic for any alphaviral disease, and a growing economic and public health burden, there is a serious need for the development of specific therapies.