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Papers of the Week
Treatment of Chronic Venous Ulcers With Heterologous Fibrin Sealant: A Phase I/II Clinical Trial.
Abstract
Heterologous fibrin sealant (HFS) consists of a fibrinogen-rich cryoprecipitate extracted from buffalo blood and a thrombin-like enzyme purified from snake venom. This study evaluated the safety and immunogenicity of HFS, estimated the best dose, and assessed its preliminary efficacy in the treatment of chronic venous ulcers (CVU).