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Papers of the Week

2021 Mar 09

Life Sci

Chlorogenic Acid retards cartilaginous endplate degeneration and ameliorates intervertebral disc degeneration via suppressing NF-κB signaling.


Ge Q, Ying J, Shi Z, Mao Q, Jin H, Wang P-E, Chen J, Yuan W, Tong P, Li J
Life Sci. 2021 Mar 09:119324.
PMID: 33711382.


Intervertebral Disc Degeneration (IDD) is a key factor involved in low back pain (LBP) which affects approximately 540 million individuals worldwide. Chlorogenic Acid (CGA), a natural compound, exerts anti-inflammatory property in several diseases. Here, we aim to investigate the biological effect of CGA on IDD and explore the underlying mechanism.