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Papers of the Week

2021 Mar 06

Pharmacoepidemiol Drug Saf

Women are started on a lower daily dose of metoprolol than men irrespective of dose recommendations.


Hendriksen LC, Verhamme KMC, Van der Linden PD, Stricker BH, Visser LE
Pharmacoepidemiol Drug Saf. 2021 Mar 06.
PMID: 33675258.


Current guidelines have no sex-specific dosage advice for metoprolol. To evaluate whether women and men are prescribed the same dose a cohort analysis was performed in the population-based Rotterdam Study (RS). Results were replicated in the Integrated Primary Care Information (IPCI) database of automated general practice data.