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Papers of the Week

2021 Mar 03

Am J Obstet Gynecol

Association between postmenopausal vulvovaginal discomfort, vaginal microbiota and mucosal inflammation: Vaginal microbiome and treatment response in postmenopausal women.


Mitchell CM, Nanxun M, Mitchell M AJ, Wu MC, Valint M D, Sean Proll M, Reed SD, Guthrie KA, LaCroix AZ, Larson M JC, Pepin R, Raftery D, Fredricks DN, Srinivasan S
Am J Obstet Gynecol. 2021 Mar 03.
PMID: 33675793.


Half of all postmenopausal women report symptoms of vulvar, vaginal or urinary discomfort with significant impact on sexual function and quality of life; underlying mechanisms leading to symptoms are poorly understood. To examine the possibility that the vaginal microbiota and/or mucosal immune response contribute to the severity of bothersome vaginal symptoms we conducted a substudy of samples from a randomized trial of vaginal treatment for genitourinary syndrome of menopause (GSM) to compare these features between women whose symptoms improved vs. those who did not.