I am a
Home I AM A Search Login

Papers of the Week

Papers: 6 Mar 2021 - 12 Mar 2021

Animal Studies

2021 Feb 25

J Neuroimmunol


Are sensory neurons exquisitely sensitive to interleukin 1β?


Stemkowski PL, Bukhanova-Schulz N, Baldwin T, de Chaves E P, Smith PA
J Neuroimmunol. 2021 Feb 25; 354:577529.
PMID: 33676084.


Peripheral nerve injury frequently evokes chronic neuropathic pain. This is initiated by a transient inflammatory response that leads to persistent excitation of dorsal root ganglion (DRG) neurons by inflammatory cytokines such as interleukin 1β(IL-1β). In non-neuronal cells such as lymphocytes, interleukin 1 exerts actions at attomolar (aM; 10 M) concentrations. We now report that DRG neurons in defined-medium, neuron-enriched culture display increased excitability following 5-6 d exposure of 1aM IL-1β. This response is mediated in part by type 1 interleukin receptors and involves decreased function of putative K1.1 channels. This finding provides new insights into the neuroimmune interactions responsible for neuropathic pain.