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Papers of the Week

Papers: 27 Feb 2021 - 5 Mar 2021

Pharmacology/Drug Development

2021 Mar 01

Nat Commun



Degradable polymeric vehicles for postoperative pain management.


Brigham NC, Ji R-R, Becker ML
Nat Commun. 2021 Mar 01; 12(1):1367.
PMID: 33649338.


Effective control of pain management has the potential to significantly decrease the need for prescription opioids following a surgical procedure. While extended release products for pain management are available commercially, the implementation of a device that safely and reliably provides extended analgesia and is sufficiently flexible to facilitate a diverse array of release profiles would serve to advance patient comfort, quality of care and compliance following surgical procedures. Herein, we review current polymeric systems that could be utilized in new, controlled post-operative pain management devices and highlight where opportunities for improvement exist.