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Papers of the Week

2021 Feb 24

BMC Pregnancy Childbirth



A case of recurrence of adult-onset Still’s disease in the third trimester: a case report and literature review.


Hosoya S, Sadatsuki M, Izuka S, Yamashita H, Oishi H
BMC Pregnancy Childbirth. 2021 Feb 24; 21(1):163.
PMID: 33627085.


Adult-onset Still's disease (AOSD) is a self-inflammatory disease showing macrophage and neutrophil activation by inflammatory cytokines such as TNF-α, IL-6, and IL-18. Although some cases with the flare of AOSD during pregnancy have been reported, most had flares in the first or second trimester and few had flares in the third trimester. In this report, we present the case of a patient with recurrent flare of AOSD in the third trimester and discuss the management of AOSD in the third trimester with the review of previous literatures.