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Papers of the Week
Morphine-3-glucuronide upregulates PD-L1 expression TLR4 and promotes the immune escape of non-small cell lung cancer.
Abstract
Patients with cancer pain are highly dependent on morphine analgesia, but studies have shown a negative correlation between morphine demand and patient outcomes. The long-term use of morphine may result in abnormally elevated serum morphine-3-glucuronide (M3G) levels. Hence, the effects of M3G on tumor progression are worth studying.