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Papers of the Week

2021 Feb 15

Cancer Biol Med



Morphine-3-glucuronide upregulates PD-L1 expression TLR4 and promotes the immune escape of non-small cell lung cancer.


Wang K, Wang J, Liu T, Yu W, Dong N, Zhang C, Xia W, Wei F, Yang L, Ren X
Cancer Biol Med. 2021 Feb 15; 18(1):155-171.
PMID: 33628591.


Patients with cancer pain are highly dependent on morphine analgesia, but studies have shown a negative correlation between morphine demand and patient outcomes. The long-term use of morphine may result in abnormally elevated serum morphine-3-glucuronide (M3G) levels. Hence, the effects of M3G on tumor progression are worth studying.